Abstract
Background: Irritable bowel syndrome is the most prevalent gastrointestinal disease characterized by recurrent abdominal pain or discomfort associated and relieved by defecation. Irritable Bowel Syndrome (IBS) is the most common functional gastrointestinal disorder where no obvious structural or biochemical etiology can be found. It is two times more prevalent in women than in men. Objective: In this study, we aim at giving an overview of IBS and the pathophysiology, predisposing factors, and management options. Methodology: We searched the PubMed database looking for relevant articles. Three mesh terms "Irritable Bowel Syndrome," "Pathophysiology", and "Management" were used. Conclusion: Irritable Bowel Syndrome (IBS) is a multifactorial disease in which one or multiple factors might be involved. It is classified according to the stool pattern to IBS with constipation, diarrhea, mixed, or unclassified. Management should involve and target various pathways, including the predominant symptoms and the believed predisposing factors, such as psychosocial factors, diet modifications, or enhance gut microbiota. Copyright (C) 2013 - All Rights Reserved - Pharmacophore