Abstract
Introduction: The formation of reactive oxygen species (ROS) is a normal consequence of essential biochemical processes. Objectives of the study: The main objective of the study is to find the role of antioxidants in chronic liver metastasis patients in Pakistan. Material and methods: This cross sectional study was conducted in Health department of Punjab during March 2018 to September 2018. The data was collected from 100 patients of hepatitis who visited the OPD of the hospital regularly. This study was carried out on 100 patients who were categorized into two groups i.e., control and HCV patients. The blood was collected from a cuboital vein of patients and serum was separated within one hour by centrifugation. Results: The data was collected from 100 patients. The level of SOD, CAT, GSH and MDA were decreases in diabetic HCV patients as compared to normal and simple HCV patients. The important biomarker is MDA and SOD. Significant differences according to the patients gender and age were observed in the groups, but neither age nor gender influenced changes in the GST and GSH levels. Conclusion: It is concluded that antioxidants levels have been related to various disease processes and play a significant role in the pathogenesis of liver complications. Their plasma levels are usually used as a marker of lipid peroxidation.