Abstract
In the present study, forty one steroid candidates containing a pyrazole ring were screened for their anti-androgenic and anti-prostate cancer activities. Also, in the same time these compounds were screened for their EGFR and VEGFR-2 kinase inhibitor potencies comparable to that of the Delphinidin. Initially, all the candidates were less toxic than the reference drug concerning LD50 values. Some of the compounds exhibited better anti-androgenic, anti-prostate cancer and EGFR and VEGFR-2 kinase inhibitor activities than the reference drugs Bicalutamide and Delphinidin, respectively. The detailed anti-androgenic, anti-prostate cancer and EGFR and VEGFR-2 kinase inhibitor activities and toxicity (LD50) of the synthesized compounds were reported.