Abstract
The enhancement in cancer chemotherapy through incorporation into solid lipid nanoparticles (SLN) drug delivery system carries a lot of potential. Improving tumor diffusivity, improvement of body distribution, enhancing cellular uptake and inhibiting multidrug resistance mechanism are the main attributes. The availability of variety of methods of preparation with scale up possibility and the higher biocompatibility of elements used may accelerate their arrival to the pharmaceutical market. Nanostructured lipid carriers (NLC) and lipid hybrid nanoparticles provide options to overcome some of SLN limitations. This review provides a thorough update on the development in SLN optimization toward chemotherapy improvement.