Abstract
Maxillofacial reconstructions, oral implants, esthetic facial procedures, regenerative procedures, etc. are highly dependent on successful regeneration of tissues. Healing of both hard and soft tissues has become one of the greatest challenges faced in clinical research in the development of bioactive surgical additives responsible for regulating inflammation and increasing healing. Understanding the process og healing at microcellular level is still not complete, but it is a proven fact that platelets do play an important role in wound healing. The potential benefit of biologic therapy has evolved with the addition of growth factors and reparative cells being the trailblazers which not only augment the normal body healing process but also restore normal form and function. Platelet-rich fibrin (PRF) represents a new step in the platelet gel therapeutic concept with simplified processing minus artificial biochemical modification. The purpose of this paper is to shed light on its clinical application in various oral surgical procedures.