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Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches
Journal article   Peer reviewed

Absolute Configuration of Alkaloids from Uncaria longiflora through Experimental and Computational Approaches

Fatimah Salim, Yusri Mohd Yunus, El Hassane Anouar, Khalijah Awang, Moses Langat, Geoffrey A. Cordell and Rohaya Ahmad
Journal of natural products (Washington, D.C.), Vol.82(11), pp.2933-2940
22/11/2019
PMID: 31686505

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Plant Sciences Science & Technology
The structure elucidation of three new alkaloids named isoformosaninol (1), formosaninol (2), and longiflorine (3), isolated from the leaves of Uncaria longiflora var. pteropoda (Miq.) Ridsdale, along with their biosynthetic pathways are discussed. Their absolute structures were determined through a combination of physical data interpretation and quantum chemical calculations using the time-dependent density functional theory (TDDFT) method.

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