Abstract
Abstract only
Introduction:
Hypertension (HTN) is a condition that contributes significantly cardiovascular disease. Little is known about the effect of recurrent major depressive disorder (rMDD) on HTN.
Methods:
This was a retrospective cohort study using the Nationwide Inpatient Sample database to identify admissions in adults with a diagnosis of HTN and rMDD in 2019. Regression models were adjusted for demographic variables and hospital characteristics. Primary outcome was all-cause mortality, and secondary outcomes were length of stay (LOS) and total charge in USD.
Results:
Out of 9,582,450 admissions with hypertension, 114,480 had rMDD. Compared to Non-rMDD-HTN cohort, rMDD-HTN cohort had more females, younger age, White, Medicaid, private insured, self-pay, median household income, and fewer Black, Hispanic, API , highest household income. rMDD-HTN cohort had more AIDS, alcohol abuse, drug abuse, chronic pulmonary disease, and less arthropathies, dementia, PVD, and diabetes mellitus. rMDD-HTN cohort had lower all-cause mortality rate (0.40% vs 1.70%,p<0.001), all-cause lower mortality OR 0.38 (95%CI 0.30-0.47,p<0.001), longer mean LOS of 1.90 days (95%CI 1.74-2.05,p<0.001) with mean LOS of 6.73 days vs 4.63 days, and total hospitalization charge -$15,428.93 (95%CI -$16,964.47- -$13,893.38,p<0.001).
Conclusion:
In patients admitted with HTN, the presence of rMDD was associated with a lower all-cause mortality rate, lower odds of all-cause mortality, longer LOS, and lower total hospitalization charge. rMDD was associated with more female, younger age, White, Medicaid as well as higher prevalence of AIDS, alcohol abuse, drug abuse and chronic pulmonary disease.