Abstract
Introduction: Human papillomavirus (HPV) is a virus infection and can lead to different epithelial lesions and cancer. Nevertheless, HPV infection is a disease that can be prevented with vaccine. Genital warts, cancer, and HPV infections can all be prevented with this vaccine. In this study, we aimed to investigate awareness, knowledge of HPV infection, and acceptance of its vaccine among the general population in Saudi Arabia.Methodology: An observational cross-sectional study was conducted in Eastern Province, Saudi Arabia between September and October 2022, using a self-administered validated questionnaire. beginning with informed consent, followed by questions about demographic data. Finally, there were questions about participants' knowledge, awareness, and attitudes around HPV and its vaccine.Rustles: The results showed 645 participants and only 4% of them had received their HPV vaccination. Knowledge, awareness, and attitude levels were all 35% with mean of 1.14, 28% with mean of 3.03, and 51% with mean of 2.02, respectively. Social media was found to be the most reliable source of information about the HPV vaccine (33%), followed by health practitioners (21%). The most common reasons for refusing vaccinations are "belief we are healthy" (48%), followed by "lack of information" (38%). Conclusion: Regarding HPV infection and its vaccination, Saudi Arabia significantly lacks knowledge and awareness. It is essential to provide instructions and information in schools for students, families, and healthcare providers about infection and its vaccination.