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Accessing the amide functionality by the mild and low-cost oxidation of imine
Journal article   Peer reviewed

Accessing the amide functionality by the mild and low-cost oxidation of imine

Magdi A. Mohamed, Ken-ichi Yamada and Kiyoshi Tomioka
Tetrahedron letters, Vol.50(26), pp.3436-3438
01/07/2009

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
Oxidation of imines using sodium chlorite under buffered conditions gave the corresponding amides in good to high yield. The reaction was generally fast and was completed within 5-40 min. As has been established in the corresponding oxidation of aldehyde, so-called Pinnick oxidation, the good functional group tolerance and the use of inexpensive reagents are the advantages of this protocol. (C) 2009 Elsevier Ltd. All rights reserved.

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