Monocyclic cis and trans amino beta-lactams are acetylated with 2-bromo-2-phenylacetyl chloride in aqueous sodium bicarbonate solution. The same reaction with 6-aminopenicillanic acid follows a different pathway and produces an oxazolone.
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Title
Acetylation of the amino group in beta-lactams under aqueous conditions: Effects of ring sizes
Creators - without role
Indrani Banik - Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, 1515 Holcombe Blvd, Houston, TX 77030 USA
Ram Naresh Yadav - Veer Bahadur Singh Purvanchal University
Ajay K. Bose - Stevens Institute of Technology
Bimal Krishna Banik - Prince Mohammad bin Fahd University
Publication Details
Journal of the Indian Chemical Society, Vol.96(10), pp.1343-1346
Publisher
Elsevier
Number of pages
4
Grant note
US NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
US NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
US Kleberg Foundation