Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

Aniruddha J. Deshpande; Monica Cusan; Vijay P.S. Rawat; Hendrik Reuter; Alexandre Krause; Christiane Pott; Leticia Quintanilla-Martinez; Purvi Kakadia; Florian Kuchenbauer; Farid Ahmed; Eric Delabesse; Meinhard Hahn; Peter Lichter; Michael Kneba; Wolfgang Hiddemann; Elizabeth Macintyre; Cristina Mecucci; Wolf-Dieter Ludwig; R. Keith Humphries; Stefan K. Bohlander; Michaela Feuring-Buske; Christian Buske

doi:10.1016/j.ccr.2006.08.023

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Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

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Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

Aniruddha J. Deshpande, Monica Cusan, Vijay P.S. Rawat, Hendrik Reuter, Alexandre Krause, Christiane Pott, Leticia Quintanilla-Martinez, Purvi Kakadia, Florian Kuchenbauer, Farid Ahmed, …

Cancer cell, Vol.10(5), pp.363-374

01/11/2006

DOI: https://doi.org/10.1016/j.ccr.2006.08.023

PMID: 17097559

Abstract

HUMDISEASE

A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. Furthermore, depletion of B220 + cells in leukemic transplants impaired development of leukemia in recipients. As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells. These data demonstrate in a murine leukemia model that AML can be propagated by a transformed progenitor with lymphoid characteristics, which can be targeted by antibodies that do not crossreact with normal HSCs.

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Title: Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia
Creators - without role: Aniruddha J. Deshpande - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Monica Cusan - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Vijay P.S. Rawat - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Hendrik Reuter - Clinical Cooperative Group Leukemia, GSF-National Research Center for Environment and Health, D-81377 Munich, Germany
Alexandre Krause - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Christiane Pott - University Hospital Schleswig-Holstein
Leticia Quintanilla-Martinez - Institute of Pathology, GSF, D-85758 Neuherberg, Germany
Purvi Kakadia - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Florian Kuchenbauer - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Farid Ahmed - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Eric Delabesse - Hôpital Necker-Enfants Malades
Meinhard Hahn - German Cancer Research Center
Peter Lichter - German Cancer Research Center
Michael Kneba - Institute of Pathology, GSF, D-85758 Neuherberg, Germany
Wolfgang Hiddemann - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Elizabeth Macintyre - Hôpital Necker-Enfants Malades
Cristina Mecucci - University of Perugia
Wolf-Dieter Ludwig - Department of Hematology, Oncology, and Tumor Immunology, Robert-Rossle-Klinik, D-13125 Berlin, Germany
R. Keith Humphries - BC Cancer Agency
Stefan K. Bohlander - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Michaela Feuring-Buske - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Christian Buske - Department of Medicine III, Klinikum Grosshadern, D-81377 Munich, Germany
Publication Details: Cancer cell, Vol.10(5), pp.363-374
Publisher: Elsevier Inc
Identifiers: 9934308608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article