Abstract
Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25 - 473.59 mu M. Compounds 8, 2, and 10 have IC50 values 31.25 +/- 1.32, 34.40 +/- 0.66, and 37.24 +/- 0.4 mu M, respectively. Standard n-propylgallate showed an IC50 value 30.12 +/- 0.27 mu M. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6 - 450.89 mu M. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 +/- 1.6 mu M).