Abstract
Acylhydrazide Schiff bases 1-27 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 16 (IC50 = 199.82 +/- 10.6 mu M), 27 (IC50 = 234.83 +/- 10.28 mu M), 2 (IC50 = 240.99 +/- 4.2 mu M), and 14 (IC50 = 276.2 +/- 2.3 mu M) showed antiglycation potential comparable to the standard rutin (IC50 = 294.50 +/- 1.5 mu M). From this study we identified a new series of potent antiglycating agents. A structure-activity relationship has been described, while all compounds were characterized by using different spectroscopic techniques.