Abstract
Three new hypoestenone (
1) diterpenes, namely, deoxyhypoestenone, dehydrohypoestenone and hypoestene, were isolated and characterized from the aerial parts of
H. forskalei. The stereochemical structures were based on their spectral data.
The aerial parts of
Hypoestes forskalei yielded three new fusicoccane diterpene ketones, named deoxyhypoestenone, dehydrohypoestenone and hypoestene. The structure and relative stereochemistry of the diterpenes were based on
1H and
13C NMR data, mainly 2D NMR experiments, including
1H
1H long range COSY,
1H
13C long range HETCOR and
1H
1H NOESY correlations, as well as chemical derivation of deoxyhypoestenone to its corresponding 8(9)α-epoxy derivative.