Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique

Weisheng Yue; Guilin Zhang; Ping Liu; Jianqi Sun; Yeukuang Hwu; Jung Ho Je; Mingguang Tan; Yan Li

doi:10.1016/j.nimb.2007.05.032

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Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique

Journal article

Peer reviewed

Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique

Weisheng Yue, Guilin Zhang, Ping Liu, Jianqi Sun, Yeukuang Hwu, Jung Ho Je, Mingguang Tan and Yan Li

Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, Vol.262(2), pp.304-312

01/09/2007

DOI: https://doi.org/10.1016/j.nimb.2007.05.032

Abstract

Lung inflammation

Phase-contrast X-ray imaging

PM2.5

Shanghai

Synchrotron radiation

Adverse health effects are associated with the inhalation of a variety of atmospheric particles. To study the lung injuries caused by aerosol PM2.5, synchrotron radiation (SR) X-ray phase-contrast imaging technique was used. Nude mice were inoculated with PM2.5 samples collected from suburban area (JD), industrial area (BS) and traffic tunnel (DPQ) of Shanghai. From X-ray phase-contrast images of lung tissues, apart from blood vessels and structures of alveoli, even hemorrhage spots of several microns caused by the inflammation were clearly observed. The studies showed that the PM2.5 samples collected from the traffic tunnel (DPQ) produced higher level of lung injury, followed by the aerosol samples collected from industrial area (BS) and suburban area (JD). Our studies also helped us to understand the process of lung injuries caused by aerosol particles.

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Title: Aerosol-induced lung injuries observed by synchrotron radiation X-ray phase-contrast imaging technique
Creators - without role: Weisheng Yue - Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Guilin Zhang - Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Ping Liu - Shanghai Jiao Tong University
Jianqi Sun - Shanghai Jiao Tong University
Yeukuang Hwu - Institute of Physics, Acamemia Sinica, Nankang, Taipei, China
Jung Ho Je - Pohang University of Science and Technology
Mingguang Tan - Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Yan Li - Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
Publication Details: Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms, Vol.262(2), pp.304-312
Publisher: Elsevier B.V
Identifiers: 9942191808331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article