Abstract
Reinvestigation of the secondary metabolites from the marine mangrove fungus
Aigialus parvus BCC 5311 led to the isolation of six new nonaketide metabolites, aigialomycins F (
4) and G (
5a/
5b), 7′,8′-dihydroaigialospirol (
7), 4′-deoxy-7′,8′-dihydroaigialospirol (
8), and rearranged macrolides
9 and
10, along with six previously described compounds, hypothemycin (
1), aigialomycins A (
2) and B (
3), aigialospirol (
6), 4-
O-demethylhypothemycin (
11), and aigialone (
12). The structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data in combination with chemical means.
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