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Alkyl, unsaturated, (hetero)aryl, and N-protected alpha-amino ketones by acylation of organometallic reagents
Journal article   Peer reviewed

Alkyl, unsaturated, (hetero)aryl, and N-protected alpha-amino ketones by acylation of organometallic reagents

Alan R Katritzky, Khanh N B Le, Levan Khelashvili and Prabhu P Mohapatra
Journal of organic chemistry, Vol.71(26), pp.9861-9864
22/12/2006
PMID: 17168609

Abstract

Stable and easily accessible N-acylbenzotriazoles, derived from a variety of aliphatic, unsaturated, (hetero)aromatic, and N-protected alpha-amino carboxylic acids, were reacted with Grignard and heteroaryllithium reagents to afford corresponding ketones in good to excellent yields.

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