Abstract
A simple, precise and sensitive method in which, a nano optical sensor binuclear Pt-2-aminobenzimidazole-bipyridine, Pt(abi)(bpy) complex doped in sol gel is used for the early diagnosis of liver cancer. The idea depends on the assessment of the concentration of alpha fetoprotein (AFP) in the serum samples of different liver patients. The nano binuclear Pt(abi)(bpy) has strong emission spectrum upon excitation at 380 nm in distilled water. The assessment of alpha fetoprotein (AFP) depends on the quenching of the emission spectrum of the optical sensor at 610 nm in water by the alpha fetoprotein (AFP). The calibration plot was achieved over the concentration 5.0 – 350 U L−1 with a correlation coefficient of 0.997 and a detection limit of 3.0 U L−1. The method was used satisfactorily for the diagnosis of liver cancer in a number of serum samples collected from various patients and health state; healthy (≤ 30 U L−1), Virus B (42.2–69.5 U L−1), Virus C (75.7–98.4 U L−1), Cirrhosis (112–147 U L−1) and HCC (185.2–349.6 U L−1). Furthermore, the assessment of the alpha-fetoprotein by the proposed method increases its sensitivity (92.88%) and specificity (91.41%) for early diagnosis of HCC.
A simple, precise and sensitive method in which a new nano optical sensor binuclear Pt-2-aminobenzimidazole-Bipyridine, Pt(abi)(bpy) complex doped in sol gel is used to the early diagnosis of liver cancer. The idea depends on the assessment of the activity of alpha fetoprotein (AFP) in the serum samples of different liver patients. [Display omitted]
•Nano optical sensor binuclear Pt(abi)(bpy) complex was prepared and characterized.•The optical sensor is used for early diagnosis of different liver diseases.•The diagnosis process depends on the assessment of AFP in serum samples.•The method was validated against the standard method.