Abstract
The impact of individual and combined treatment of artificial food additives on oxidative stress, antioxidant parameters and pancreatic disruptor in male albino rats will be examined in this study. Six groups of young albino rats (80 - 100 gm) were examined Group I: (Control untreated group), Group II, III, IV and V: treated with ADI of MSG (300 mg / kg), Sodium benzoate (5 mg / kg), Carmoisine (4 m g / kg), and EDTA (2.5 mg / kg) respectively. Group VI: treated with mixture of tested materials simultaneously., The treatments were carried out orally for 28 days. The obtained results revealed production of malondialdehyde MDA and protein carbonyl PC indicators of oxidative stress in individually treated MSG and sodium benzoate and remarkable in mixture group. Significant reduction in catalase, total antioxidant capacity, and glutathione content were recorded in individually treated groups and pronounced in mixture group. Elevation in serum glucose level and alteration in pancreatic enzymes amylase and lipase, as well as insulin, were recorded.