Abstract
Ochratoxin A is one of the most important mycotoxins in fish feed. In the present study the effects of OTA on cultured Oreochromus niloticus were evaluated. Trials for ameliorate the drastic effect of OTA were done by using active life yeast and whey. The results indicted that significant (p<0.05) decrease in RBCS, WBCS, phagocytic activity and phagocytic index were occurred in both levels of OTA. Hypoalbuminemia, hypoproteinemia, decrease of globulin, and antibody titer as well as increase of liver enzymes, creatinine and uric acid were noticed. The histopathological examination showed that OTA caused diffuse hydropic degeneration and advanced fatty changes in liver. Tubular necrosis and hydropic degeneration of the kidneys were observed. The activation of melano macrophage centers (MMCs) were recorded. The results proved that OTA produce serious physiological, immunological and pathological effects on, O.niloticus. Morovere active life yeast and whey were succeed to neutralize the drastic toxic effects of OTA.
[Mansour, T.A, Safinaz, G. Mohamed, Soliman, M.K. Eglal, A. Omar, Srour, T.M., Mona S. Zaki and Shahinaz, M. H. Hassan. Ameliorate the Drastic Effect of Ochratoxin A by using Yeast and Whey in Cultured Oreochromus niloticus in Egypt. Life Science Journal. 2011; 8(1):68-81] (ISSN: 1097-8135). http://www.lifesciencesite.com.