Abstract
Diabetes is characterized by hyperglycemia. Secondary complications of diabetes are serious risk factors that might lead to cardiovascular diseases. This study evaluated the effects of methanolic extract of Carica papaya fruit and seed in ameliorating the abnormal structural changes in myocardium and functional impairment induced by diabetes in albino rats. The experimental animals were divided into control (C), induced type II diabetes (D), protected seed extract (PSE), protected fruit extract (PFE), treated seed extract (TSE), and treated fruit extract (TFE). The myocardium of diabetic group exhibited disorganized myocardial fibers. Regard both normal, seed and fruit extract groups, which are of almost similar normal pattern of regular oriented muscle fibers. The diabetic group exhibited increased myocardial lipid peroxidation coincides with depletion of superoxide dismutase and increase of the levels of creatine kinase, troponin-1, nuclear factor Kappa B, caspase 3, tumor necrosis factor-alpha, and activity of lactic dehydrogenase. The diabetic group showed intense dark brown immune reaction against alpha-smooth muscle actin and P53. Experimental diabetic group protected with either seed and fruit extract exhibited marked amelioration of the assessed parameters. In conclusion, both seed and fruit extract of Carica papaya are of potential medical importance through managing high glucose level and keep myocardium against diabetes-induced cell death.