Abstract
Three new amides,
N-salicyloyl-2-aminopropan-1,3-diol (
1), 1-acetyl-
N-salicyloyl-2-aminopropan-3-ol (
2) and
N-salicyloyl-2-aminopropan-1-ol (
3) were isolated from an ethyl acetate extract of the culture filtrate of a fungus,
Streptomyces hygroscopicus.
Three amides,
N-salicyloyl-2-aminopropan-1,3-diol (
1) and 1-acetyl-
N-salicyloyl-2-aminopropan-3-ol (
2) including a natural product,
N-salicyloyl-2-aminopropan-1-ol (
3) were isolated from an ethyl acetate extract of the culture filtrate of a fungus,
Streptomyces hygroscopicus. The structures of these compounds were unambiguously established by interpretation of their spectral data including, a series of 1D and 2D-NMR and MS analyses. Compounds
1–
3 showed significant antibacterial activity against a wide range of Gram positive and Gram negative bacteria.