Abstract
The complex formation equilibria in the reaction of [Pd(en)(H2O)(2)](2+) with 4,4-bipiperidine (Bip) and DNA constituents such as inosine, inosine-5-monophosphate, uracil, uridine, thymine, and thymidine were investigated at 25 degrees C and 0.1M ionic strength. The [(H2O)(en)Pd(Bip)Pd(en)(H2O)](4+) complex and its hydrolyzed species were formed. Substitution of coordinated water by inosine (Ino) as DNA constituent formed the complexes [(Ino)(en)Pd(Bip)Pd(en)(H2O)](3+) and [(Ino)(en)Pd(Bip)Pd(en)(Ino)](2+). The formation of the binuclear complexes was further supported by spectral measurements. The formation constants of all possible mono- and binuclear complexes were determined and their speciation diagrams were evaluated.