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Amino acids in the syntheses of heterocyclic systems: Syntheses and radiostability of novel biologically active triazoles containing the sulfonamide moiety
Journal article   Peer reviewed

Amino acids in the syntheses of heterocyclic systems: Syntheses and radiostability of novel biologically active triazoles containing the sulfonamide moiety

AMSh El-Sharief, M Ghorab, MSA El-Gaby, ShI Mohamed and Y A Ammar
Heteroatom chemistry, Vol.13(4), pp.316-323
01/01/2002

Abstract

Antibiotics Irradiation Spectroscopic analysis Sterilization (cleaning) Synthesis (chemical)
A number of novel triazoles 2a-f, 4, 9, 10, 12, 15; triazolothiadiazoles 6, 8, 11, 16; triazolothiadizine 5; and triazolotriazine 14 were synthesized and characterized by elemental analyses and spectral data. Six of the compounds showed antifungal activity compared with the fungicide Mycostatine. Radiosterilization of the biologically active compounds 4, 8, 9b, and 10 in the dry state may prove to be applicable at the sterile dose 25 kGy.

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