Aminoalkylation of nitriles by iminium ions generated in situ

Alan R. Katritzky; Ashraf A.A. Abdel-Fattah; Peter J. Steel

doi:10.1016/j.tetlet.2005.12.059

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Aminoalkylation of nitriles by iminium ions generated in situ

Journal article

Peer reviewed

Aminoalkylation of nitriles by iminium ions generated in situ

Alan R. Katritzky, Ashraf A.A. Abdel-Fattah and Peter J. Steel

Tetrahedron letters, Vol.47(9), pp.1465-1467

27/02/2006

DOI: https://doi.org/10.1016/j.tetlet.2005.12.059

Abstract

Aminoalkylation

N-(α-Aminoalkyl)benzotriazoles

β-Aminoalkyl nitriles

Aminoalkylation of a series of primary and secondary nitriles with N-(α-aminoalkyl)benzotriazoles 1 (derived from a variety of secondary amines and aldehydes) proceeds smoothly providing the corresponding β-aminoalkyl nitriles 5a– j in 66–97% yields.

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Details

Title: Aminoalkylation of nitriles by iminium ions generated in situ
Creators - without role: Alan R. Katritzky - University of Florida
Ashraf A.A. Abdel-Fattah - University of Florida
Peter J. Steel - University of Canterbury
Publication Details: Tetrahedron letters, Vol.47(9), pp.1465-1467
Publisher: Elsevier Ltd
Identifiers: 9934668708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article