Aminoalkylbenzotriazoles: reagents for the aminoalkylation of electron rich heterocycles

Alan R. Katritzky; Zhijun Yang; Jamshed N. Lam

doi:10.1016/S0040-4020(01)81590-8

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Aminoalkylbenzotriazoles: reagents for the aminoalkylation of electron rich heterocycles

Journal article

Peer reviewed

Aminoalkylbenzotriazoles: reagents for the aminoalkylation of electron rich heterocycles

Alan R. Katritzky, Zhijun Yang and Jamshed N. Lam

Tetrahedron, Vol.48(23), pp.4971-4978

05/06/1992

DOI: https://doi.org/10.1016/S0040-4020(01)81590-8

Abstract

Mannich Reaction/C-Alkylation/Lewis Acid/Indole/Pyrrole/Furan

Secondary and tertiary aminoalkylbenzotriazoles react with pyrrole, indole, their N-methyl analogs and with 2-methylfuran under mild reaction conditions in the presence of a Lewis acid to afford selectively the corresponding secondary or tertiary amines. Secondary and tertiary aminoalkylbenzotriazoles react with indoles, pyrroles and 2-methylfuran under mild conditions in the presence of a Lewis acid to afford selectively the corresponding C-aminoalkylated secondary and tertiary amines.

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Title: Aminoalkylbenzotriazoles: reagents for the aminoalkylation of electron rich heterocycles
Creators - without role: Alan R. Katritzky - University of Florida
Zhijun Yang - University of Florida
Jamshed N. Lam - University of Florida
Publication Details: Tetrahedron, Vol.48(23), pp.4971-4978
Publisher: Elsevier Ltd
Identifiers: 9935219108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article