Abstract
A three-component reaction of 1 mol of arylhydrazonals with 2 mol of an active methylene compound is realized under pressure to obtained novel functionalized pyridazines with a 96% atom economy. The reaction of arylhydrazonals with active methylene compounds under pressure, ultrasound irradiation, and conventional heating is studied, and the reactions yields, and times are compared. The developed protocol is characterized by environmental friendliness, the use of low-cost catalysts and available starting materials, short reaction times, and high yields, and involves no column chromatography. The reaction offers up to a 96% atom economy and a 100% carbon capture.