Abstract
[GRAPHICS]
The chemical reactivity of 4-amino-6-benzyl-3-mercapto-1,2,4-triazine- 5( 4H)-one ( 1) towards various aliphatic or/and mono and bis aromatic carboxylic acid derivatives to give the corresponding fused heterocyclic systems, 1,3,4-thiadiazoles 4-6, which incorporating 1,2,4-triazine nucleus was achieved. Moreover, compound 1 was subjected to react either with halo acetic acids or bromo ester to afford the respective fused nitrogen ring junction systems, thiadiazole 2 and 3, or thiadiazine 7. However, the tetracyclic ring system 9 was furnished through condensation reaction of isatine with triazine 1. In addition, some of the new synthesized compounds were evaluated as an antioxidant and antitumor agents.