Abstract
Here, we describe a simple method to synthesize the starting intermediate 2-amino-8-benzylidene-4-phenyl-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (6) by the reaction of 2,6-dibenzylidene cyclohexanone with malononitrile in the presence of triethyl amine under solvent-free conditions. The o-amino carbonitrile compound 6 was used as a versatile precursor for synthesis of novel heterocyclic compounds fused to the 4H-chromene ring system heterocycles 7-17 such as chromenopyrimidines, chromenoimidazopyrimidine, chromenopyrimidotriazepinone, and chromenotriazolopyrimidine. The chemical structures of the newly synthesized compounds were established on the basis of elemental and spectral analyses including melting point, thin-layer chromatography, Fourier transform infrared spectroscopy, H-1-NMR, and mass spectroscopy, hoping these molecules would allow us to investigate their pharmacological activities in future studies.