Abstract
Background: Grindstone technique has been widely used as an efficient, consistent, more environmentally benign, solvent-free protocol for the preparation of many compounds with higher atom economy.
Methods: A series of fourteen piperonal chalcone compounds were synthesized by this method and characterized by physical and spectral data (FT-IR, H-1 NMR, Mass and elemental analysis). All chalcones Were evaluated for their cytotoxic action against the cancer cell lines, MCF-7 and HepG2. One 2-pyridyl-substituted compound 14 with IC50 values 17.4 +/- 0.2 towards MCF-7 and 15.4 +/- 0.6 mu mol L-1 towards HepG2 cells.
Results: The results demonstrated that the cytotoxic activity of 2-pyridyl-substituted compound shown higher activity as compared with the standard cisplatin towards HepG2 cells.
Conclusion: Compound 14 showed good antioxidant activities in the DPPH test and H2O2 assay (IC50 = 17.23 +/- 33/mu g/mL and 20.17 +/- 0.33 mu g/mL) when compared with the standard ascorbic acid (1C(50) = mu g/mL 18.26 +/- 0.22 and 21.66 +/- 1.06 mu g/mL).