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An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3 ']-pyrrolidine and Spiro[oxindole-3,2 '-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction
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An Expedient Regio- and Diastereoselective Synthesis of Hybrid Frameworks with Embedded Spiro[9,10]dihydroanthracene [9,3 ']-pyrrolidine and Spiro[oxindole-3,2 '-pyrrolidine] Motifs via an Ionic Liquid-Mediated Multicomponent Reaction

Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, J. Carlos Menendez, Mujeeb A. Sultan, Usama Karama, Hazem A. Ghabbour and Hoong-Kun Fun
Molecules (Basel, Switzerland), Vol.20(9), pp.16142-16153
01/09/2015
DOI: https://doi.org/10.3390/molecules200916142
PMCID: PMC6332494
PMID: 26404224

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Life Sciences & Biomedicine Physical Sciences Science & Technology
A series of hitherto unreported anthracene-embedded dispirooxindoles has been synthesized via a one-pot three-component 1,3-dipolar cycloaddition reaction of an azomethine ylide, generated in situ from the reaction of isatin and sarcosine to 10-benzylideneanthracen-9(10H)-one as a dipolarophile in 1-butyl-3-methylimidazolium bromide([bmim]Br), an ionic liquid. This reaction proceeded regio- and diastereoselectively, in good to excellent yields.
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https://doi.org/10.3390/molecules200916142View
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