Abstract
Piperazine scaffolds are a group of heterocyclic atoms having pharmacological values and showing
significant results in pharmaceutical chemistry. Piperazine has a flexible core structure for the design and synthesis
of new bioactive compounds. These flexible heterogenous compounds exhibit various biological roles, primarily
anticancer, antioxidant, cognition enhancers, antimicrobial, antibacterial, antiviral, antifungal, antiinflammatory,
anti-HIV-1 inhibitors, antidiabetic, antimalarial, antidepressant, antianxiety and anticonvulsant
activities, etc. In the past few years, researchers focused on the therapeutic profile of piperazine synthons for
different biological targets. The present review highlights the development in designing pharmacological activities
of nitrogen-containing piperazine moiety as a therapeutic agent. The extensive popularity of piperazine as a
drug of abuse and their vast heterogeneity research efforts over the last years motivated the new investigators to
further explore this area.