An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

Said A S Ghozlan; Khadija O Badahdah; Ismail A Abdelhamid

doi:10.1186/1860-5397-3-15

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An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

Journal article

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An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues

Said A S Ghozlan, Khadija O Badahdah and Ismail A Abdelhamid

Beilstein journal of organic chemistry, Vol.3(1), pp.15-15

01/05/2007

DOI: https://doi.org/10.1186/1860-5397-3-15

PMCID: PMC1885264

PMID: 17470302

Abstract

Chemistry

Full Research Paper

3-Oxo-2-arylhydrazononitriles 1a-c react readily with chloroacetonitrile, ethyl chloroacetate, and with phenacyl chloride to give 4-aminopyrazoles 4a-e . The pyrazolo[4,3- d ]pyrimidine derivatives 7 and 10 are synthesized via reaction of the aminopyrazole 4b with phenylisothiocyanate and DMFDMA/NH 4 OAc respectively.

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Title: An easy synthesis of 5-functionally substituted ethyl 4-amino-1-aryl- pyrazolo-3-carboxylates: interesting precursors to sildenafil analogues
Creators - without role: Said A S Ghozlan - King Abdulaziz University
Khadija O Badahdah - King Abdulaziz University
Ismail A Abdelhamid - King Abdulaziz University
Publication Details: Beilstein journal of organic chemistry, Vol.3(1), pp.15-15
Publisher: Beilstein-Institut
Identifiers: 9935938608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article