Abstract
Fluoro-substituted zinc(II)phthalocyanines (RS)(4)ZnPcs were prepared. All the structures of newly synthesized compounds was evaluated by IR and H-1 NMR spectral analysis. They were tested against human adenocarcinoma prostate cancer cells. A type II membrane antigen highly expressed in prostate cancer, namely prostate-specific membrane antigen, has been an attractive target for imaging and therapy. To investigate the structure-activity relationships of (RS)(4)ZnPcs 4a-c in human adenocarcinoma prostate cancer cell model, 3 fluoro-substituted zinc(II)phthalocyanines with different terminal heteroaromatic rings have been designed and evaluated for their anti-proliferative potency in vitro. The detailed LD50 values of the targeted compounds were reported. Our preliminary in vitro studies confirm that (RS)(4)ZnPcs 4a-c could act as an attractive photosensitizer for the early diagnosis of prostate cancer.