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An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs
Journal article   Peer reviewed

An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs

Khalid Mohammed Khan, Itrat Fatima, Syed Muhammad Saad, Muhammad Taha and Wolfgang Voelter
Tetrahedron letters, Vol.57(5), pp.523-524
03/02/2016
DOI: https://doi.org/10.1016/j.tetlet.2015.12.067

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
An efficient protocol has been developed for the one-pot synthesis of tetrazole derivatives in moderate to good yields starting from substituted benzaldehydes and proceeding via non-isolated oxime and nitrile intermediates. The structures of the desired products were confirmed by IR, and NMR spectroscopy as well as mass spectrometry. A plausible reaction mechanism is also discussed. (C) 2015 Elsevier Ltd. All rights reserved.

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