Abstract
An efficient, eco-friendly and sustainable approach for the synthesis of novel spiroindeno[1,2-b]quinoxa line-3-phenylspiro[4,3 '']benzylidenepiperidone ring system has been developed by a one-pot four component [3 + 2] cycloaddition strategy. The 1,3-dipole generated in situ from quinoxalinone and I.phenylalanine reacts with the highly functionalized dipolarophiles, bisarylidene piperidones affording spirohybrid heterocycles in good yields. The unexplored novel class of dispirohybrid heterocycles obtained possess three C-N and two C-C bonds with four adjacent stereogenic carbons, out of which two is spirocarbons. The structure of compounds was elucidated using H-1, C-13 and mass spectroscopic studies. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.