Abstract
The present investigation is in the interest of one-pot, environmentally friendly and efficient protocol for the synthesis of quinoline derivatives from 2-aminoarylketones and active methylene compounds in the presence of L-proline and ionic liquid 1,3-dimethylimidazolium methyl sulfate [MMIm][MSO4]. The Ionic liquid which is used as a catalyst can be reused several times. The results obtained by using [MMIm][MSO4] were also compared with those described in the literature. The advantages of the method are shorter reaction time, milder conditions, easy workup and better yields. The catalyst [MMIm][MSO4] can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency. This method of synthesis widens the applicability of Ionic liquids in heterocyclic compounds.