Abstract
We report here a facile, one-pot, environmentally friendly, and efficient protocol for the synthesis of quinoline derivatives from the condensation of 2-aminoarylketones and active methylene compounds catalyzed by inexpensive, nontoxic and environmentally benign FeCl3.6H(2)O catalyst. The results obtained by using FeCl3.6H(2)O catalyst were also compared with those described in the literature. This methodology offers several advantages such as shorter reaction time, milder conditions, easy workup, and better yields. The non-extractive workup/purification, economic and environmentally benign catalyst make this operationally straightforward procedure affordable for a large scale.