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An improved synthesis of Biginelli-type compounds via phase-transfer catalysis
Journal article   Peer reviewed

An improved synthesis of Biginelli-type compounds via phase-transfer catalysis

Bahar Ahmed, Riaz A. Khan, Habibullah and Manoj Keshari
Tetrahedron letters, Vol.50(24), pp.2889-2892
17/06/2009
DOI: https://doi.org/10.1016/j.tetlet.2009.03.177

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
3,4-Dihydropyrimidin-2(1H)-one, 3,4-dihydropyrimidin-2(1H)-thione, and 3,4-dihydropyrimidin-2(1H)-imine derivatives were synthesized by modified Biginelli cyclocondensation reaction in a time-efficient manner with near quantitative yields starting from appropriately substituted aromatic aldehyde, beta-ketoester and either urea, thiourea or guanidine as constituent synthons using tetra-butyl ammonium bromide (TBAB) as catalyst for the first time. (C) 2009 Published by Elsevier Ltd.

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