An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah; Shamsuddeen A. Haladu; Basem A. Mosa

doi:10.1016/j.tetlet.2010.10.164

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An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Journal article

Peer reviewed

An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase

Nisar Ullah, Shamsuddeen A. Haladu and Basem A. Mosa

Tetrahedron letters, Vol.52(2), pp.212-214

12/01/2011

DOI: https://doi.org/10.1016/j.tetlet.2010.10.164

Abstract

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

An improved total synthesis of spermatinamine, an inhibitor of the anticancer target, isoprenylcysteine carboxy methyltransferase (Icmt) was accomplished from the commercially available 3,4-dibromo-4-hydroxybenzaldehyde via a high yielding reaction sequence in an overall yield of 31%. (C) 2010 Elsevier Ltd. All rights reserved.

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Title: An improved total synthesis of spermatinamine, an inhibitor of isoprenylcysteine carboxy methyltransferase
Creators - without role: Nisar Ullah - King Fahd University of Petroleum and Minerals
Shamsuddeen A. Haladu - King Fahd University of Petroleum and Minerals
Basem A. Mosa - King Fahd University of Petroleum and Minerals
Publication Details: Tetrahedron letters, Vol.52(2), pp.212-214
Publisher: Elsevier
Number of pages: 3
Grant note: FT090014 / KFUPM
Identifiers: 9914945608331
Academic Unit: Imam Abdulrahman Bin Faisal University; King Fahd University of Petroleum & Minerals; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article