Abstract
Infections of
(
) are major threats to health, threats include diarrhoea, fever, acute intestinal inflammation, and cancer. Nevertheless, little information is available about the involvement of
in colon cancer etiology.
The present study was designed to predict nuclear targeting of
proteins in the host cell through computational tools, including nuclear localization signal (NLS) mapper, Balanced Subcellular Localization predictor (BaCeILo), and Hum-mPLoc using next-generation sequencing data.
Several gene expression-associated proteins of
have been predicted to target the host nucleus during intracellular infections. Nuclear targeting of
proteins can lead to competitive interactions between the host and pathogen proteins with similar cellular substrates, and it may have a possible involvement in colon cancer growth. Our results suggested that
releases its proteins within compartments of the host cell, where they act as a component of the host cell proteome. Protein targeting is possibly involved in colon cancer etiology during intracellular bacterial infection.
The results of current in-silico study showed the potential involvement of
infection with alteration in normal functioning of host cell which act as possible factor to connect with the growth and development of colon cancer.