Abstract
The charge-transfer (CT) interaction of the widely used antihypertensive drug valsartan (Val) with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ), tetrafluoro-1,4-benzoquinone (TFQ), and 7,7,8,8-tetracya noquinodimethane (TCNQ) resulted in new CT complexes [(Val)(DDQ)], [(Val)(TFQ)], and [(Val)(TCNQ)] that were characterized by Fourier transform infrared (FTIR) and ultraviolet-visible (UV/Vis) spectroscopies. The CT complexes were prepared in two non-polar solvents: dichloromethane (CH2Cl2) and trichloromethane (CHCl3) at room temperature. Val reacted with the acceptors via a 1:1 M ratio by donation electrons from Val's biphenyl rings to the aromatic ring of the acceptor (pi ->pi* interaction). Spectral results and the Benesi-Hildebrand approach were used to estimate the following spectroscopic parameters for the newly generated CT complexes: molar absorptivity (epsilon(max)), association constant (K-CT), energies parameters [ionization potential (I-P), interaction energy (E-CT), standard free energy change (Delta G degrees), and resonance energy (R-N)], transition dipole moment (mu), and oscillator strength (f). Statistical analyses indicated a strong correlation among several of these spectroscopic parameters. (C) 2022 Elsevier B.V. All rights reserved.