Abstract
Introduction: An accurate and precise spectrophotometric method has been developed for the determination of the antiallergenic drug, promethazine with ruthenium (III).
Methods: The proposed method involves complexation of promethazine with Ru (III) (PM. Ru(III)) at 60 degrees C and lambda(max) = 510 nm, which is applicable in pharmaceutical tablets and analytical data. The values for Beer's law, molar absorptivity, Sandell's sensitivity, and mean correlation coefficient were determined to be 0.2(-28) mu g mL(-1), 1.54 x 10(3) L mol(-1) cm(-1), 0.021 and 0.9996, respectively.
Conclusion: The complex of promethazine with Ru(III) was characterised using FTIR, H-1-NMR, ESR, magnetic susceptibility, thermal (TG-DTA), and PXRD. The most plausible structure for the complex is reported with molecular formula [C37H52ClN4O2RuS2]center dot 3Cl. The proposed method could be implemented for an easy and effective analysis for promethazine.