Abstract
The electrochemical behavior of alverine at carbon paste electrodes has been investigated in 0.04 M Britton-Robinson buffer pH 6.25 using cyclic and differential pulse voltammetric methods. Cyclic voltammetric studies indicated that the oxidation of alverine was irreversible adsorption controlled process. Experimental and instrumental parameters were optimized, and a sensitive differential pulse adsorptive anodic stripping procedure has been investigated for determination of the drug over the concentration range, 0.47 - 6.15 mu g/ml alverine citrate, with detection and quantification limits of 0.14 and 0.47 mu g/ml alverine citrate, respectively. The proposed method was successfully applied to the determination of alverine citrate in its pharmaceutical formulation.