Abstract
Synthetic benzophenone-bis-Schiff bases (1-17) were evaluated for PC3 cell line inhibition. Most of the compounds showed cytotoxic effects but compounds 4, 8, 14, 16, and 17 were found to be potent. The growth inhibition of PC3 cells was in a concentration-dependent manner when treated with compounds 4, 8, 14, 16 and 17 (Figure-2) after 24 h exposure time. The IC50 values of all five most active compounds were calculated as 4 (IC50 = 24 + 1.4 mu M), 8 (IC50 = 29 +/- 1.3 mu M), 14 (IC50 = 66 +/- 2.8 mu M), 16 (IC50 = 28 +/- 1.4 mu M) and 17 (IC50 = 18 +/- 2.8 mu M) when compared with standard cisplatin (IC50 = 20 +/- 1.1 mu M). This study has identified potent anticancer agents.