Abstract
The application of nanoparticles in the clinical field is of great interest. The aim of this study is to explore the hypothesis that gold and silver nanoparticles could play a positive role in ameliorating the biochemical changes accompanied diabetic nephropathy in experimental model. Rats were treated orally with silver or gold nanoparticles for 21 days after DN induction. Our results showed significant regression of blood glucose level and serum AGEPs accompanied by increase in serum insulin level in DN treated with silver, and gold nanoparticles compared to DN induced group. Also, gold and silver nanoparticles remarkably recovered kidney function biomarkers including urea, creatinine, uric acid albumin and micro albumin in treated group as compared to DN induced group. In addition, kidney fibrotic markers cystatine C, fibronectin, TGF-beta, Laminine and transferine, showed progressive enhancement in DN treated with silver and gold nanoparticles compared to DN induced experimentally. In Conclusion; the present study highlighted the biological effect of AgNPS, and AuNPS in ameliorating DN induced experimentally through anti-fibrotic and anti-diabetic effect.