Abstract
A series of substituted pyridine derivatives from 2-chloro-6-ethoxy-4-acetylpyridine (1-10) which was previously synthesized, were screened for their antiinflammatory activities using the model of granuloma induced via cotton pellet and showed potent antiinflammatory activities confirmed by carrageenan animal model. Measuring the level of plasma prostaglandins showed reduction of PGE2 by the tested compounds. The mechanism of antiinflammatory activities was COX-1 inhibitors, confirmed via evaluation of COX-1/COX-2 ratio. These compounds also have good antipyretic activities and lower ulcerogenic causing probabilities.