Abstract
The binuclear [Pd2(kappa 2-ptt)4] (1) and mixed ligand complexes of the type [Pd(kappa 1-S-ptt)2(kappa 2-diamine)] (2-4) (Hptt is 1-phenyl-1H-tetrazole-5-thiol), diamine; ethylene diamine (en), 1,10-phenanthroline (Phen) or 2,2'-bipyridyl (Bipy) as co-ligands have been synthesized. The obtained complexes were characterized by elemental analysis, 1H-, 13C-{1H} NMR, molar conductivity, UV-Vis and IR spectroscopy. In complex 1 the ptt anion coordinated as a bridging bidentate via the thione sulfur atom and deprotonated nitrogen atom of the heterocyclic ring to afford a dimeric complex. Whereas in 2-4 the ptt bonded as a monodentate through the thiolato sulfur atom, while the diamine ligands are coordinated as bidentate chelates to afford a square planner arrangement around the Pd(II) center. The anti-fungal activity of the prepared complexes (1-4) was tested against two fungi types (Candida albicans, and Aspergillus niger). All the complexes showed moderate activity compared to standard Fluconazole. Moreover, the anti-cancer activity of complexes (2-4) were examined against ovarian and breast cancer cells. Cell viability assays show that complexes (2-4) are promising anti-tumor in vitro.