Abstract
Avocado (Persea americana) seeds represent under-utilised resources and waste issues in avocado processing. This study was produced to compare the lipid contents of the avocado bulb and seed. The study also evaluated the anti-oxidant, anti-inflammatory and anti-cancer potentiality of each extract. Oleic acid was the predominant unsaturated fatty acid in a chloroform/methanol extract of P. americana fruit and seed. The seed extract was richer with sterol compounds than the fruit extract. The extracts exhibited anti-inflammatory and anti-cancer activities against cell line of colon cancer (HCT116) and cell line of liver cancer (HePG2) in a dose-dependent manner. It also exhibited powerful scavenging of free radical by using- DPPH and ABTS. IC50 of seed extract against the aforementioned cancer cell lines was more or less near the values of a reference drug (sorafinib). In conclusion, P. americana seed extract has more powerful effects than avocado bulb extract. The seeds should not be neglected. (C) 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University.