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Anti-tumour activity of some polydentate N-ligands: N,N-bis-(3-substituted-5-methylpyrazol-1yl methyl) arylamines and N,N,N',N'-tetra[(3-substituted-5-methylpyrazol-1yl] para-phenylenediamines
Journal article   Peer reviewed

Anti-tumour activity of some polydentate N-ligands: N,N-bis-(3-substituted-5-methylpyrazol-1yl methyl) arylamines and N,N,N',N'-tetra[(3-substituted-5-methylpyrazol-1yl] para-phenylenediamines

T Ben Hadda, A T Kotchevar, M Daoudi, B Bennani, N Ben Larbi and A Kerbal
Letters in drug design & discovery, Vol.2(8), pp.584-589
01/12/2005
DOI: https://doi.org/10.2174/157018005774717299

Abstract

Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Five polydentate ligands 2-6 were prepared from arylamines and precursors 1a-b. The polydentate (2-4) and (5) showed marked activity against cancer cell lines. The substituents (R and R') appear to play a key role in the cytotoxic potency of this class of compounds.

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